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    LSM: Introduction to Prodrugs and Related Technology

    Thursday, 4 October, 2018 - 16:00 to Thursday, 25 October, 2018 - 18:00
    Vesalius 07.100 (ALO): follow wayfinding sign nr 5 (Alma Leercentrum Onderwijstoren)
    Vesalius 07.100 (ALO): follow wayfinding sign nr 5 (Alma Leercentrum Onderwijstoren)

    Introduction to Prodrugs and Related Technology

    Short-type PhD level course (3 x 2h) – Michel Guillaume, PhD. – October 2018

    This course consists of 3 modules of 2 hours each:

    •          Module 1: Thursday 4 October, 16-18h

    •          Module 2: Thursday 11 October, 16-18h

    •          Module 3: Thursday 25 October, 16-18h

    Location: Vesalius 07.100 (ALO): follow wayfinding sign nr 5 (Alma Leercentrum Onderwijstoren): You can download the floor plan here.

    Registration: send email to phd@gbiomed.kuleuven.be with subject ‘Registration Prodrugs’

    Please take note of our no-show policy

     

    Background

    Dr. Michel Guillaume is a Principal Scientist at Janssen, Pharmaceutical Companies of Johnson & Johnson. During the last 12 years, besides his main activity in the Chemical Development Department, Dr. Guillaume has been involved with the design and development of prodrugs derived from active compounds at different clinical stages.

    Prodrugs are pharmacologically inactive compounds which, after appropriate activation through a degradative mechanism (e.g. hydrolysis or redox decomposition), are transformed into an active ingredient available to fulfil its primary goal.

    A prodrug program was developed based mainly on two monographs:

    1. "Prodrugs: Challenges and rewards" (Parts 1 & 2), edited by Prof. Valentino Stella, Prof. Em. from the University of Kansas, a recognized authority in the field of prodrugs.
    2. "Hydrolysis in Drug and Prodrug Metabolism" written by Bernard Testa, Prof. Em. from the University of Lausanne. Prof. Testa is a recognized authority in the field of drug-related metabolism and prodrugs.

    In addition, public domain case studies on Nalmefene dodecanoate will be presented, based on material published in collaboration with the KU Leuven[1] and Janssen Pharmaceuticals.

    The course will consist of 3 modules of 2 hours each, with the content detailed in the next sections.

    Students can only get credits for this course if they pass a test organized at the end of the course.

    Find the detailed programme in the attachment below